Creatine: The Next Great Antioxidant?

Muscle damage is a natural consequence of exercise. A small amount of muscle damage is not a terrible thing and, in fact, is necessary to stimulate new muscle growth. If, on the other hand, the amount of damage you inflict upon your muscles with exercise exceeds their capacity to repair and rebuild, then you’re in big trouble. You then have a scenario of net muscle breakdown, otherwise known as catabolism. Situating yourself in a catabolic holding pattern by continually overdoing it in the weight room will eventually lead to overall loses in muscle mass and diminished athletic performance. This article focuses one aspect of overtraining and how to minimize its effects.

Two principal forms of muscle damage arise from physical exertion:

The first is mechanical and occurs immediately. In response to the physical stress of exercise, your muscles and associated capillary beds become slightly damaged. These microscopic foci of damage may then prime a robust phase of increased micro-vascularization and new muscle growth (aka, anabolism). That is, conditions permitting, capillary beds will reform to increase blood flow and new muscle tissue will be laid down to replace damaged tissue. The end result, increased blood flow to larger, more efficiently, working muscles. If, on the other hand, the initial amount of damage is too great or insufficient time is given for your muscles to fully recover from the insult, you will lose strength and mass!

The second form of muscle damage is a downstream consequence of the first and is, in actuality, the initiation of the rebuilding process discussed previously. This form of muscle damage results from reactive molecular species produced in response to strenuous exercise, but that exert their degenerative effects a few days later.

Rising from the ashes …

Following the initial insult of exercise, damaged muscle tissue must be cleared away before rebuilding can commence. This process begins with the leakage of chemical agents from damaged cells that attract specialized cells known as phagocytes (neutrophils and macrophages) to sites of damage. Here, phagocytes accumulate, greatly increase in number, and build an appetite. Next, commences a voracious phase of cell eating, otherwise known as phagocytosis (hence, their name), whereby damaged muscle tissue is literally eaten away. The process of phagocytosis is initiated with the release of agents from macrophages that serve to breakdown, or digest, damaged cells in preparation for absorption. Following the removal of all dead tissue, the stage is then set for new muscle growth. New muscle is formed from the fusion of hundreds of progenitor cells that were previously laying dormant waiting for the appropriate signal to act. From start to finish, this entire process takes about 3-4 days.

Free Radicals

To assist in their removal of dead tissue phagocytes release digestive enzymes, toxins, and, most importantly, Reactive Oxygen Species, or ROS, for short. ROS are produced in the burst of metabolic activity known as a “respiratory burst“. One of the most powerful of ROS produced by phagocytes is the Superoxide Radical. Superoxide greatly weakens the integrity of the muscle membrane causing small tears that allow calcium ions to leak into the muscle cell. It is a rise in intramuscular calcium that activates a class of enzyme known as proteases that cause the muscle cell to disintegrate. Obviously, a small amount of superoxide plays an essential role in the absorption of damaged cells. On the other hand, overproduction of superoxide surpasses its usefulness and can actually be counterproductive as its destructive capacity becomes unleashed without warrant..

Oxidative stress

Exercise also directly produces ROS. That is, independently of neutrophils and macrophages. Normally, most of the oxygen consumed during cell metabolism is converted into water. A small amount of the consumed oxygen (2-4%), however, is converted into superoxide. Given the fact that exercise can increase muscle oxygen consumption by as much as 200-fold, superoxide levels also increase tremendously with intense exercise, easily surpassing the body’s capacity to neutralize it. This gives rise to a dangerous scenario known as oxidative stress, which slows muscle recovery and increases the chances of injury. In fact, some experts believe that the overproduction of ROS may also accelerate the normal aging process as well as eventually lead to states of disease.

Antioxidants

Our bodies possess a natural line of defense against oxidative stress; special molecules known as antioxidants that neutralize ROS. Vitamins A, C and E are examples of vitamins that can act as antioxidants. Vitamin E is a particularly potent antioxidant, since it is able to act in both aqueous (within the cell) and lipid (within membranes) environments, and is hence very effective at protecting our cellular membranes from degradation following oxidative stress. Our bodies also come equipped with their own antioxidant molecular complexes. Some of the most important enzymatic antioxidants are Superoxide Dismutase, Glutathione Peroxidase, and Catalase. Glutathione is one of our principle non-enzymatic antioxidants.

Athletes are now paying closer attention to their antioxidant status in an attempt to better assist muscle recovery. Proactive measures one can take to enhance the body’s capacity to cope with oxidative stress include eating foods rich in antioxidants, supplementing with antioxidant vitamins, limiting alcohol intake, especially following exercise and getting plenty of rest. It now turn’s out that some athletes were improving their antioxidant defenses in a way they hadn’t previously imagined…

Is creatine an antioxidant?

A study was recently released suggesting that creatine might act as a superoxide scavenger in its own right. This would be an additional benefit of creatine, independent of its better-understood capacity to increase ATP availability during exercise. It is thus possible that part of the benefit we obtain from creatine derives from its capacity to act as an antioxidant.

The salient points of the study were as follows:

  1. The creatine levels used in this study were within physiological limits. In other words, the concentrations of creatine found by this study to be effective at scavenging free radicals were comparable to those found within muscle (20-60 mM, for those interested). This gave relevancy to the study.
  2. Creatine, although not as effective as glutathione at neutralizing superoxide, was an effective antioxidant, nonetheless.
  3. Creatine’s ability to neutralize superoxide was measured in a test tube, not in an exercising person. And, although it’s reasonable to assume that creatine should behave similarly within athletes, subtle differences may exist. For all we know, creatine may be an even more efficacious antioxidant inside the body! Only further experimentation will tell.

Take Home

This report indicates that creatine possess’ antioxidant properties and is able to effectively neutralize Superoxide, one of the more insidious free radicals produced by exercise. Since these findings where obtained in a test tube, however, it remains to be shown if creatine has the same antioxidant properties within an exercising person. Although preliminary, this result is surely worth pursuing and has important practical implications for muscle recovery following strenuous exercise.

Scientific References

1. Lawler, J. M., Barnes, W. S., Wu G., Song, W., and Demaree, S. (January 2002) Direct antioxidant properties of creatine. Biochemical and Biophysical Research Communications Volume 290 (1): pages 47-52.

 

This article was written by Dr. Alfredo Franco-Obregón, research scientist, author, and owner of the Creatine Information Center and NSN Publishing.

Dr. Alfredo Franco-Obregón has had over 20 years of in depth research experience in major laboratories world-wide. His principal scientific interest is the understanding of the cellular mechanisms leading to muscle cell death.

Dr. Franco-Obregón is also the author of Creatine: A practical guide. Creatine: A practical guide clearly teaches you how to best combine exercise, nutrition, and intelligent creatine use for optimal muscle growth, improved athletic performance, and overall good health. Find out more about this must-read book.

3 Easy Tips To Lose Fat

Fat loss does not have to be difficult, especially if you have a few tricks up your sleeve.  By this I don’t mean I would ever want you to take a dangerous, radical approach to your fat loss but only one that would be healthy and prove great results at the same time.

I have had many clients, friends and family members ask me, “Isabel, is there a way I can drop my first few pounds of fat quickly and easily?”  Yes, there is.  It will require a few dietary changes on your part, but the results are incredible.  I have had hundreds of people use these tips with great success, easily losing their first 10-15lbs of unwanted fat.

Here are my 3 Simple and Easy Fat Loss Rules:

1. Don’t eat anything that is white. Name every single food that is white and chances are you shouldn’t be eating it: bread, pasta, crackers, most cereals, flour based products, white potatoes, white rice, and pasteurized dairy and cheese are all no-no’s during this time.  (Healthy foods like cauliflower, chicken, turkey, fish, white pork are all exceptions to this rule).

2. Only drink water, NOTHING else! How about coffee? Just to keep any possible withdrawal headaches at bay, one small cup of organic black coffee. Can you add half and half?…Well is it white?  Drink a minimum of 1/2 of your bodyweight in ounces of water each day (ex. If you weigh 200 lbs, you need to drink 100 ounces) to really see the fat fall off.

3. Don’t eat anything with the word wheat in the ingredients list. What if it’s whole wheat? Look, if the word starts with W and ends in T and has the letters h e a in between, you can’t eat it.  This includes bread, pasta, crackers and cereal.  Many packaged snack foods also contain wheat so be sure to read the ingredients list carefully.

Are you up for this challenge?  Apply these easy fat loss rules to your own eating plan for the next 2 weeks and I know you will be seeing some amazing fat loss results in no time.

Receive your free diet and nutrition tips in your email inbox every week by signing up for our Free Nutrition Report.

Get started on your own personal fat burning meal plans right away with The Diet Solution Program.

How to Avoid Over-training to Maximize Muscle Growth

Almost anyone that’s picked up a set of weights has or will experience symptoms of over-training at one point in there muscle building program. Over-training can lead to serious injury, chronic fatigue, and even muscle loss.

Over-training is very common amongst athletes and particularly bodybuilders, since they figure that training as much as possible is the fastest way to massive muscle gains.

This couldn’t be any further from the truth however…

Training too much, or at too high of an intensity will lead to over-training.

Now this doesn’t mean you don’t have to put plenty of effort in to see some decent results… Whether you are a bodybuilder, athlete, or just someone that wants to add some additional mass to your frame, you need to train hard and be consistent-that’s a given. In order to get the most out of your genetics, you have to progressively overload the muscles by increasing the weight and / or intensity of each weight training workout.

The problem is however, that many of us increase the intensity of our workouts or get insufficient amounts of rest, or even worse, a combination of both. The trick is finding the right balance between workout volume and intensity, and rest and recovery. And that is exactly what I’ll cover in this article.
The Effects of Over-Training on Bodybuilders

First, let’s take a look at some of the effects of over-training and how one can prevent over-training from happening in the first place.

The Effects of Over-training on the Nervous System

Over-training effects both the sympathetic and parasympathetic nervous systems in the following negative ways:

  • Higher resting heart rate
  • Weak appetite
  • High blood pressure
  • Weight loss
  • Trouble sleeping
  • Increased metabolic rate
  • Irritability
  • Early onset of fatigue

If you are experiencing more than one of the symptoms outlined above, you may be in a state of over-training, and should evaluate your routine as soon as possible.

The Effects of Over-training on Hormone Levels

Many studies have indicated that over-training negatively effects the levels of hormones, as well as the hormone response in the body.  Since hormones play such an important role in the muscle building process, this can have a detrimental effect on your training progress.

Over-training has been show to:

  • Decrease testosterone levels
  • Decrease thyroxine levels
  • Increase cortisol levels
The increase in cortisol levels along with the decrease in testosterone levels is a deadly combination, since this leads to protein tissue break down. This will ultimately lead to a loss of muscle tissue.  

The Effects of Over-training on the Immune System

perhaps one of the most alarming repercussions of over-training is it’s negative impact on the immune system-you’re bodies first defense against harmful viruses and bacteria.

Over-training can drastically decrease the levels of antibodies and lymphocytes in your body, making you much more susceptible to illness.  Simply put, this means that if you are in a state of over-training, you are much more likely to get sick.  Since you will have to skip workouts while you are sick, your muscle building progress will slow considerably.

The Effects of Over-training on the Metabolic System

Here is a list of how over-training can  effect the metabolic system.  These symptoms are the ones that are most commonly discussed, and are ones we can’t ignore:

  • Micro tears in the muscle
  • Chronically depleted glycogen levels
  • Slow, weak muscle contractions
  • Depleted creatine phosphate stores
  • Excessive accumulation of lactic acid
  • Extreme DOMS (delayed onset muscle soreness)
  • Tendon and connective tissue damage

So you must get the point by now… Over-training effects the entire body, and can seriously impact the results of your muscle building program.  

Now let’s take a look at the different types of over-training, and what we can do to prevent it.

Is it Worse to Over-Train With Cardio or Weight Training?

Any form of over-training is a bad thing, however, I’ve personally experienced both types of over-training and can honestly say that over-training in the weight room is much worse, and much more prevalent than over-training through cardiovascular training.

Here are some of the reasons why: 

  • In order to grow, muscles must fully recover from their last workout, every workout.  If you are over-training and work the muscles before they have fully recovered, you will break down the muscle tissue before it has rebuilt-making it impossible to build muscle!
  • Over-training with weights makes you more susceptible to nervous systems hormone and immune system issues, which all pose serious health risks.
  • It can lead beginners down the wrong path, perhaps wasting money on unnecessary supplements, or even worse, steroids.

I personally believe that only competitive athletes such as swimmers, runners and bikers run a serious risk of reaching a state of cardiovascular over-training, since there are often training for two or more hours daily. 

The bottom line is that it is much easier for the average person to over-train while weight training than while cardiovascular training, and I think the effects can be more serious.

How do I Determine if I’m Over-training?

Determining if you’re currently over-training is fairly simple.   If you’re in tune with your body, you can often see the signs of over-training before they get serious.  If you are losing interest in workouts, are having trouble sleeping, and feel weak and irritable, you may be in a state of over-training and should take a week or more off.

If you are experiencing two or more of the symptoms outlined earlier in the article, this should raise a red flag. 

Another variable you can use to determine if you are over-training is by tracking the performance of your workouts. 

Has your physical performance improved compared to your last workout?

For example, let’s say last workout you were able to perform 8 pull-ups using your body-weight, but were only able to perform 6 pull-ups the following week.  This means that you have not “out done” your previous workout, have not fully recovered, and therefore are likely over-training.  You nave to re-asses your program and make modifications so that you see progress every workout. 

How Can I Prevent Over-training?

n order to avoid over-training, you need to take a multi-facited approach.  Determining the correct training volume and intensity, eating the right foods, and getting the right amount of rest and recovery must all be taken in to consideration.  Now let’s take a look at each of those factors in more detail.

Correct Training Volume 

Determining the correct training volume can be difficult, especially when you are first starting out.  You have to determine how much weight to lift, how many repetitions and set to perform for every single workout.

You need to use your own judgment in this case, based on your recovery ability and your recovery methods.  Remember that the goal is that you improve every single workout, and if this isn’t happening, you have to decrease the intensity of your workouts.

This is where many people go wrong though.  You begin your workout and realize that you have not fully recovered.  You can either continue to train at a lower intensity than the previous workout, or skip the workout entirely.

As hard as it may be, skipping the workout is the right way to go.  Just turn around and go home!  Your body is telling you that it needs more rest, and you must listen to it! 

There is no point in training at a lower intensity, further breaking down the muscle tissue.   By doing this you will increase your risk of injury, and make it harder for your body to fully recovery for your next training session.

Proper Nutrition

Your diet plays a huge role in your muscle building program.  It helps regulate hormone levels, provides energy, and provides the raw building blocks that are used to create new tissue.

Here are some dietary recommendations that will limit the chance of over-training: 

  • Do not skip breakfast.  This is one of the most important meals of the day.  Skipping breakfast is very catabolic, and can promote muscle loss.
  • Never let yourself get hungry.  If you’re trying to build muscle mass, you have to constantly feed your body quality foods so that it never has the chance catabolize muscle tissue.
  • Unless you are trying to build muscle and lose fat, make sure you have eaten prior to your training session and are not hungry.
  • Have the largest meal of the day within an hour after your workout.  Do this every single workout!
  • Consider taking proven supplements like creatine, and antioxidants to increase performance and fight free radicals.
  • Eat every 2-3 hours to ensure that your body remains in an anabolic state.
  • Keep glycogen levels at full capacity to inhibit muscle tissue breakdown. 

Rest & Recovery

Rest and recovery is essential when it comes to avoiding over-training.  Make sure that you get at least 7 hours of sleep each night, and that you are on a consistent schedule.  As for recovery time, it’s important that you have days off between weight training workouts.  Try to have one rest day between weight training workouts, and never train the same muscle groups on consecutive days. 

Everything you need to know about muscle building

Weight Training Tips

Weight training properly is known by few. If it was easy then you would see a lot more muscular and lean physiques on the streets. Before you learn how to weight train properly, it is critical that you learn these five weight training tips before you even step foot in the gym.

1. Write down a realistic short term and long term goal.

2. Make a commitment to stick to one program for at least 12 weeks.

3. Educate yourself prior to starting.

4. Hire a trainer to teach you proper technique.

5. Focus on gradual progression.
Weight Training Tip #1: Goal Setting

Inch-by-inch life is a sinch. Yard-by-yard life is hard. Treat your goal setting the same way. Do not expect to be on the cover of Men’s Health by next summer. Decide how much muscle weight you wish to achieve in three months. Six months and one year. Decide where you wish to finish and work backwards. If you wish to gain 50 pounds by the end of the year, than create a game plan that allows to gain at least one pound per week.

Weight Training Tip #2: Commitment

The only reason you will fail is if you are not truly committed to your goals. Do your homework and find a weight training program ideal for your specific goals and situation. Study the program fully prior to commencing. Comprehend every detail of the program and if you don’t, contact the author of the program to ensure you have no excuse to misunderstand or perform the workout incorrectly. After you chosen a program, take responsibility for your decision and follow it to it’s full completion. Do not try it out for three weeks and than say, “It’s not working…” and try another program. This will create a failures attitude and begin the deadly bad habit of program hopping

Weight Training Tip #3: Education

How much do you really know about building muscle? Let’s put it this way, if you had to teach someone else how to transform their body in the next twelve weeks, could you help them? Never mind, could you transform your body in the next twelve weeks? If not, you probably do not know enough about how your body works from a training, nutrition and recovery stand point. Order a book, visit a reputable website and find out everything you must know, about proper weight training, before you start the guessing game.

Weight Training Tip #4: Proper Technique

You wouldn’t try and drill your teeth? You wouldn’t try and do your own taxes? You wouldn’t try and fix your own car? Assuming you have no expertise in dentistry, accounting or automotive repairs. So why would you try and teach yourself proper weight training technique? It boggles my mind why so many people across North America sign up for a gym membership and jeopardize the health of their tendons, ligaments and joints with the attitude of “I think I’ll try it on my own,” or “My friend is going to teach me,” or “I am self taught from watching others…” Do not be cheap and leave your ego at the door and hire a reputable fitness trainer who can teach you proper weight training technique.

Weight Training Tip #5: Progression

I’ll say this again. Inch-by-inch life is a sinch. Yard-by-yard life is hard. Approach each workout with this attitude. Your bench press does not need to go up twenty pounds in the first week. But just imagine your bench press went up consistently 2.5-5 pounds every week for the next year? That would some serious muscular and strength gains! Your goal is to simply out do yourself from workout-to-workout, week-to-week. Whether you do one extra rep, one extra set, a extra 2.5 pounds or a shorter rest period, these are are measurable signs of weight training progress.

Conclusion

Make your weight training life easy by starting with the the above weight training tips and look forward to a rewarding and fruitful adventure in the gym.